ZFIN is now using GRCz12tu for Genomic Data
Gene
lrp1aa
- ID
- ZDB-GENE-030131-7889
- Name
- low density lipoprotein receptor-related protein 1Aa
- Symbol
- lrp1aa Nomenclature History
- Previous Names
-
- lrp1a
- si:dkey-40c23.4
- wu:fj39b01
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable apolipoprotein binding activity and cargo receptor activity. Acts upstream of or within regulation of vasculature development. Predicted to be located in clathrin-coated pit and organelle. Predicted to be active in plasma membrane. Is expressed in blood vessel and caudal vein plexus. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142928 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Pi et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| keratosis pilaris atrophicans | Alliance | ?Keratosis pilaris atrophicans | 604093 |
| Developmental dysplasia of the hip 3 | 620690 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR032485 | Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR051221 | Low-density lipoprotein receptor-related |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement Clr-like EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low-density lipoprotein receptor-related | NOTCH1 EGF-like calcium-binding domain | Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QD95 | InterPro | 4560 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrp1aa-201
(1)
|
Ensembl | 4,949 nt | ||
| mRNA |
lrp1aa-202
(1)
|
Ensembl | 13,518 nt | ||
| mRNA |
lrp1aa-203
(1)
|
Ensembl | 3,571 nt | ||
| mRNA |
lrp1aa-204
(1)
|
Ensembl | 3,053 nt | ||
| mRNA |
lrp1aa-205
(1)
|
Ensembl | 1,685 nt | ||
| mRNA |
lrp1aa-206
(1)
|
Ensembl | 309 nt | ||
| mRNA |
lrp1aa-207
(1)
|
Ensembl | 582 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers