Gene
cd59a
- ID
- ZDB-GENE-030131-7871
- Name
- CD59 molecule (CD59 blood group) a
- Symbol
- cd59a Nomenclature History
- Previous Names
-
- cd59
- fj38b04
- lndc1
- ly6/neurotoxin like
- wu:fj38b04
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables lipopolysaccharide binding activity and lipoteichoic acid binding activity. Acts upstream of or within defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in membrane. Is expressed in several structures, including blood; endocrine system; hypochord; nervous system; and unfertilized egg. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Wiltbank et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy | 612300 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ly-6 antigen/uPA receptor-like | Snake toxin-like superfamily | Snake toxin/toxin-like |
|---|---|---|---|---|---|
| UniProtKB:E7F2M5 | InterPro | 118 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cd59a:TagRFP) |
|
| 1 | Wiltbank et al., 2022 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-150L7 | ZFIN Curated Data | |
| Encodes | EST | fj38b04 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326385 (1) | 1077 nt | ||
| Genomic | GenBank:BX957297 (2) | 79980 nt | ||
| Polypeptide | UniProtKB:E7F2M5 (1) | 118 aa |
- Wiltbank, A.T., Steisnon, E.R., Criswell, S.J., Piller, M., Kucenas, S. (2022) Cd59 and inflammation regulate Schwann cell development. eLIFE. 11:
- Fujihara, Y., Herberg, S., Blaha, A., Panser, K., Kobayashi, K., Larasati, T., Novatchkova, M., Theussl, H.C., Olszanska, O., Ikawa, M., Pauli, A. (2021) The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization. Proceedings of the National Academy of Sciences of the United States of America. 118(39):
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Siems, S.B., Jahn, O., Hoodless, L.J., Jung, R.B., Hesse, D., Möbius, W., Czopka, T., Werner, H.B. (2021) Proteome Profile of Myelin in the Zebrafish Brain. Frontiers in cell and developmental biology. 9:640169
- Li, L., Yang, W., Shen, Y., Xu, X., Li, J. (2020) Fish complement C8 evolution, functional network analyses, and the theoretical interaction between C8 alpha chain and CD59. Molecular immunology. 128:235-248
- Zhang, J., Zhou, Y., Wu, C., Wan, Y., Fang, C., Li, J., Fang, W., Yi, R., Zhu, G., Li, J., Wang, Y. (2018) Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts. Frontiers in endocrinology. 9:756
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 10 of 12
Show