ZFIN is now using GRCz12tu for Genomic Data
Gene
cd59a
- ID
- ZDB-GENE-030131-7871
- Name
- CD59 molecule (CD59 blood group) a
- Symbol
- cd59a Nomenclature History
- Previous Names
-
- cd59
- fj38b04
- lndc1
- ly6/neurotoxin like
- wu:fj38b04
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables lipopolysaccharide binding activity and lipoteichoic acid binding activity. Acts upstream of or within defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in membrane. Is expressed in several structures, including blood; endocrine system; hypochord; nervous system; and unfertilized egg. Human ortholog(s) of this gene implicated in colorectal carcinoma; hemolytic anemia; and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Wiltbank et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy | 612300 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CD59 glycoprotein | Ly-6 antigen/uPA receptor-like | Snake toxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:E7F2M5 | InterPro | 118 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers