Gene
sema3e
- ID
- ZDB-GENE-030131-7864
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
- Symbol
- sema3e Nomenclature History
- Previous Names
-
- fj37c11
- si:ch211-120m13.2
- wu:fj37c11
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Exhibits neuropilin binding activity. Involved in sprouting angiogenesis. Predicted to localize to extracellular space and integral component of plasma membrane. Human ortholog(s) of this gene implicated in CHARGE syndrome. Is expressed in several structures, including brain; cardiovascular system; endoderm; mandibular arch skeleton; and primary motor neurons. Orthologous to human SEMA3E (semaphorin 3E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| CHARGE syndrome | WT + MO3-sema3e | standard conditions | Liu et al., 2019 |
| CHARGE syndrome | rw0Tg + MO3-sema3e | standard conditions | Liu et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR015513 | Semaphorin 3E, Sema domain |
| Domain | IPR016201 | PSI domain |
| Family | IPR027231 | Semaphorin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | Semaphorin 3E, Sema domain | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQA6
|
767 | ||||||||||
|
UniProtKB:Q1LYS1
|
768 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3e-201
(1)
|
Ensembl | 3,044 nt |
Interactions and Pathways
No data available
Plasmids
No data available