Gene
sema3e
- ID
- ZDB-GENE-030131-7864
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
- Symbol
- sema3e Nomenclature History
- Previous Names
-
- fj37c11
- si:ch211-120m13.2
- wu:fj37c11
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables neuropilin binding activity. Acts upstream of or within neural crest cell migration; regulation of photoreceptor cell axon guidance; and sprouting angiogenesis. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including cardiovascular system; endoderm; head; immature eye; and nervous system. Used to study CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| CHARGE syndrome | WT + MO3-sema3e | standard conditions | Liu et al., 2019 |
| CHARGE syndrome | rw0Tg + MO3-sema3e | standard conditions | Liu et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR015513 | Semaphorin 3E, Sema domain |
| Domain | IPR016201 | PSI domain |
| Family | IPR027231 | Semaphorin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | Semaphorin 3E, Sema domain | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PQA6 | InterPro | 767 | ||||||||||
| UniProtKB:Q1LYS1 | InterPro | 768 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3e-201
(1)
|
Ensembl | 3,044 nt |
Interactions and Pathways
No data available
Plasmids
No data available