Gene
pola2
- ID
- ZDB-GENE-030131-778
- Name
- polymerase (DNA directed), alpha 2
- Symbol
- pola2 Nomenclature History
- Previous Names
-
- wu:fb48f05
- zgc:77841
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Acts upstream of or within with a positive effect on cell population proliferation and fin regeneration. Predicted to be located in nucleus. Predicted to be part of alpha DNA polymerase:primase complex. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56124 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wang et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| as51 | Allele with one point mutation | Unknown | Missense | ENU | |
| as52 | Allele with one delins | Unknown | Unknown | CRISPR | |
| pd311 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa21243 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27160 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41166 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pola2 | (2) | |
| CRISPR2-pola2 | (2) | |
| CRISPR3-pola2 | (3) | |
| CRISPR4-pola2 | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007185 | DNA polymerase alpha/delta/epsilon, subunit B |
| Domain | IPR013627 | DNA polymerase alpha, subunit B, N-terminal |
| Domain | IPR054300 | DNA polymerase alpha subunit B, OB domain |
| Family | IPR016722 | DNA polymerase alpha, subunit B |
| Homologous_superfamily | IPR043034 | DNA polymerase alpha, subunit B, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA polymerase alpha/delta/epsilon, subunit B | DNA polymerase alpha, subunit B | DNA polymerase alpha, subunit B, N-terminal | DNA polymerase alpha, subunit B, N-terminal domain superfamily | DNA polymerase alpha subunit B, OB domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P0S9 | InterPro | 600 | |||||
| UniProtKB:B0S687 | InterPro | 600 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-186M8 | ZFIN Curated Data | |
| Encodes | EST | fb48f05 | ||
| Encodes | cDNA | MGC:56124 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77841 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199581 (1) | 2080 nt | ||
| Genomic | GenBank:BX465215 (1) | 133505 nt | ||
| Polypeptide | UniProtKB:B0S687 (1) | 600 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | POLA2 | 11 | Amino acid sequence comparison (1) |
- Roan, H.Y., Tseng, T.L., Chen, C.H. (2021) Whole-body clonal mapping identifies giant dominant clones in zebrafish skin epidermis. Development (Cambridge, England). 148(18)
- Tseng, T.L., Wang, Y.T., Tsao, C.Y., Ke, Y.T., Lee, Y.C., Hsu, H.J., Poss, K.D., Chen, C.H. (2021) The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Development (Cambridge, England). 148(15):
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Wang, Y.T., Tseng, T.L., Kuo, Y.C., Yu, J.K., Su, Y.H., Poss, K.D., Chen, C.H. (2019) Genetic Reprogramming of Positional Memory in a Regenerating Appendage. Current biology : CB. 29(24):4193-4207.e4
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mans, D.A., Vermaat, J.S., Weijts, B.G., van Rooijen, E., van Reeuwijk, J., Boldt, K., Daenen, L.G., van der Groep, P., Rowland, B.D., Jans, J.J., Roepman, R., Voest, E.E., van Diest, P.J., Verhaar, M.C., de Bruin, A., and Giles, R.H. (2013) Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. The Journal of pathology. 231(1):117-29
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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