Gene
cth
- ID
- ZDB-GENE-030131-774
- Name
- cystathionase (cystathionine gamma-lyase)
- Symbol
- cth Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to act upstream of or within cysteine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66001 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Kumai et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010139Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025536Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20749 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 3 of 3
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cth | Jiang et al., 2020 | |
| MO1-cth | N/A | (3) |
| MO2-cth | N/A | Jiang et al., 2020 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cystathioninuria | Alliance | Cystathioninuria | 219500 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR054542 | Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site |
| Family | IPR000277 | Cys/Met metabolism, pyridoxal phosphate-dependent enzyme |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site | Cys/Met metabolism, pyridoxal phosphate-dependent enzyme | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1QPF7 | InterPro | 404 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212604 (1) | 1934 nt | ||
| Genomic | GenBank:BX324166 (1) | 215450 nt | ||
| Polypeptide | UniProtKB:F1QPF7 (1) | 404 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CTH | 1 | Amino acid sequence comparison (1) |
- Jiang, W., Liu, C., Deng, M., Wang, F., Ren, X., Fan, Y., Du, J., Wang, Y. (2020) H2S promotes developmental brain angiogenesis via the NOS/NO pathway in zebrafish. Stroke and vascular neurology. 6(2):244-251
- Ayobahan, S.U., Eilebrecht, E., Kotthoff, M., Baumann, L., Eilebrecht, S., Teigeler, M., Hollert, H., Kalkhof, S., Schäfers, C. (2019) A combined FSTRA-shotgun proteomics approach to identify molecular changes in zebrafish upon chemical exposure. Scientific Reports. 9:6599
- Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179
- Geronikolou, S.A., Pavlopoulou, A., Kanaka-Gantenbein, C., Chrousos, G. (2018) Inter-species functional interactome of nuclear steroid receptors (R1). Frontiers in bioscience (Elite edition). 10:208-228
- Perna, A.F., Anishchenko, E., Vigorito, C., Zacchia, M., Trepiccione, F., D'Aniello, S., Ingrosso, D. (2018) Zebrafish, a Novel Model System to Study Uremic Toxins: The Case for the Sulfur Amino Acid Lanthionine. International Journal of Molecular Sciences. 19(5)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kovács, R., Csenki, Z., Bakos, K., Urbányi, B., Horváth, Á., Garaj-Vrhovac, V., Gajski, G., Gerić, M., Negreira, N., López de Alda, M., Barceló, D., Heath, E., Kosjek, T., Žegura, B., Novak, M., Zajc, I., Baebler, Š., Rotter, A., Ramšak, Ž., Filipič, M. (2015) Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study. Water research. 77:201-212
- Kumai, Y., Porteus, C.S., Kwong, R.W., Perry, S.F. (2015) Hydrogen sulfide inhibits Na(+) uptake in larval zebrafish, Danio rerio. Pflugers Archiv : European journal of physiology. 467(4):651-64
- Kwong, R.W., Perry, S.F. (2015) Hydrogen sulfide promotes calcium uptake in larval zebrafish. American journal of physiology. Cell physiology. 309(1):C60-9
- Porteus, C.S., Abdallah, S.J., Pollack, J., Kumai, Y., Kwong, R.W., Yew, H.M., Milsom, W.K., Perry, S.F. (2014) The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio). The Journal of physiology. 592(Pt 14):3075-88
1 - 10 of 15
Show