Gene
crygmx
- ID
- ZDB-GENE-030131-7732
- Name
- crystallin, gamma MX
- Symbol
- crygmx Nomenclature History
- Previous Names
-
- ns:zf-es20 (1)
- zgc:109980
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in lens.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903514 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35326 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta/gamma crystallin | Beta/Gamma-Crystallin | Gamma-crystallin-like |
|---|---|---|---|---|---|
| UniProtKB:Q5XTN0 | InterPro | 175 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crygmx-201
(1)
|
Ensembl | 848 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-41E15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6903514 | Thisse et al., 2004 | |
| Encodes | EST | zf-es20 | ||
| Encodes | cDNA | MGC:109980 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173690 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173691 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192042 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013262 (1) | 817 nt | ||
| Genomic | GenBank:CR751608 (2) | 209340 nt | ||
| Polypeptide | UniProtKB:Q5XTN0 (1) | 175 aa |
No data available
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Shao, M., Lu, T., Zhang, C., Zhang, Y.Z., Kong, S.H., Shi, D.L. (2020) Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation. Proceedings of the National Academy of Sciences of the United States of America. 117:7245-7254
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
- Zhang, Y., Wang, Z., Zhao, G., Liu, J.X. (2018) Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicology and environmental safety. 163:279-288
- Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuzé, A., Casane, D., Rétaux, S. (2015) Lens defects in Astyanax mexicanus cavefish: evolution of crystallins and a role for alphaA-crystallin. Developmental Neurobiology. 75(5):505-21
- Wages, P., Horwitz, J., Ding, L., Corbin, R.W., and Posner, M. (2013) Changes in zebrafish (Danio rerio) lens crystallin content during development. Molecular Vision. 19:408-417
- Gómez-Requeni, P., de Vareilles, M., Kousoulaki, K., Jordal, A.E., Conceição, L.E., and Rønnestad, I. (2011) Whole body proteome response to a dietary lysine imbalance in zebrafish Danio rerio. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 6(2):178-86
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