Gene
gsdmeb
- ID
- ZDB-GENE-030131-7662
- Name
- gasdermin Eb
- Symbol
- gsdmeb Nomenclature History
- Previous Names
-
- dfna5
- dfna5b
- fk59f08
- wu:fc41e05
- wu:fk59f08
- zgc:91916 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within with a positive effect on pyroptotic inflammatory response. Acts upstream of or within inner ear morphogenesis and regulation of biosynthetic process. Predicted to be located in endomembrane system and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including hematopoietic system; liver; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91916 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 5 | Alliance | Deafness, autosomal dominant 5 | 600994 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Gasdermin-E | Gasdermin, pore forming domain | Gasdermin, PUB domain |
|---|---|---|---|---|
|
UniProtKB:Q6J2R6
|
472 | |||
|
UniProtKB:A0A8M6YSN6
|
281 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gsdmeb-201
(1)
|
Ensembl | 2,369 nt | ||
| mRNA |
gsdmeb-202
(1)
|
Ensembl | 434 nt | ||
| mRNA |
gsdmeb-203
(1)
|
Ensembl | 1,977 nt |
Interactions and Pathways
No data available
Plasmids
No data available