Gene
gsdmeb
- ID
- ZDB-GENE-030131-7662
- Name
- gasdermin Eb
- Symbol
- gsdmeb Nomenclature History
- Previous Names
-
- dfna5
- dfna5b
- fk59f08
- wu:fc41e05
- wu:fk59f08
- zgc:91916 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within with a positive effect on pyroptotic inflammatory response. Acts upstream of or within inner ear morphogenesis and regulation of biosynthetic process. Predicted to be located in endomembrane system and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including hematopoietic system; liver; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91916 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gsdmeb | (2) | |
| CRISPR2-gsdmeb | (5) | |
| CRISPR3-gsdmeb | Tyrkalska et al., 2022 | |
| MO1-gsdmeb | N/A | Busch-Nentwich et al., 2004 |
| MO2-gsdmeb | N/A | Busch-Nentwich et al., 2004 |
| MO3-gsdmeb | N/A | (2) |
| MO4-gsdmeb | N/A | Zhang et al., 2020 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 5 | Alliance | Deafness, autosomal dominant 5 | 600994 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Gasdermin-E | Gasdermin, pore forming domain | Gasdermin, PUB domain |
|---|---|---|---|---|---|
| UniProtKB:Q6J2R6 | InterPro | 472 | |||
| UniProtKB:A0A8M6YSN6 | InterPro | 281 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gsdmeb-201
(1)
|
Ensembl | 2,369 nt | ||
| mRNA |
gsdmeb-202
(1)
|
Ensembl | 434 nt | ||
| mRNA |
gsdmeb-203
(1)
|
Ensembl | 1,977 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001947 (1) | 2350 nt | ||
| Genomic | GenBank:BX469919 (2) | 219865 nt | ||
| Polypeptide | UniProtKB:Q6J2R6 (1) | 472 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Sun, L., Yang, B., Peng, Z., Yang, T., Qin, B., Ao, J., Yang, Y., Wang, J., Zheng, L., Xie, H. (2023) Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Nascimento, L.R.D., Vieira-Silva, G.A., Kitajima, J.P.F.W., Batissoco, A.C., Lezirovitz, K. (2022) New Insights into the Identity of the DFNA58 Gene. Genes. 13(12):
- Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523
- Chen, H., Wu, X., Gu, Z., Chen, S., Zhou, X., Zhang, Y., Liu, Q., Wang, Z., Yang, D. (2021) Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases. Developmental and comparative immunology. 124:104203
- Chen, W., Zhao, J., Mu, D., Wang, Z., Liu, Q., Zhang, Y., Yang, D. (2021) Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 206(8):1913-1922
- Cheng, X.N., Zhang, J.J., Shi, D.L. (2020) Loss of Rbm24a causes defective hair cell development in the zebrafish inner ear and neuromasts. Journal of genetics and genomics = Yi chuan xue bao. 47(7):403-406
- Wang, Z., Gu, Z., Hou, Q., Chen, W., Mu, D., Zhang, Y., Liu, Q., Liu, Z., Yang, D. (2020) Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo. Journal of immunology (Baltimore, Md. : 1950). 204(7):1929-1942
- Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W., Wen, Z. (2020) Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. The Journal of biological chemistry. 295(26):8846-8856
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