Gene

mdh1ab

ID
ZDB-GENE-030131-7655
Name
malate dehydrogenase 1Ab, NAD (soluble)
Symbol
mdh1ab Nomenclature History
Previous Names
  • MDH1a (1)
  • mdh1b
  • fk59d03
  • wu:fk59d03
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have L-malate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; retinal photoreceptor layer; and solid lens vesicle. Orthologous to human MDH1 (malate dehydrogenase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdh1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 88 Alliance ?Developmental and epileptic encephalopathy 88 618959
Associated With mdh1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001252 Malate dehydrogenase, active site
Domain IPR001236 Lactate/malate dehydrogenase, N-terminal
Domain IPR022383 Lactate/malate dehydrogenase, C-terminal
Family IPR001557 L-lactate/malate dehydrogenase
Family IPR010945 Malate dehydrogenase, type 2
Family IPR011274 Malate dehydrogenase, NAD-dependent, cytosolic
Homologous_superfamily IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal Lactate/malate dehydrogenase, C-terminal Lactate/malate dehydrogenase, N-terminal L-lactate/malate dehydrogenase Malate dehydrogenase, active site Malate dehydrogenase, NAD-dependent, cytosolic Malate dehydrogenase, type 2 NAD(P)-binding domain superfamily
UniProtKB:Q7ZSY2 333
Transcripts
Genome Browsers
Type Name Length (nt) Analysis
pseudogenic transcript mdh1ab-201 (1) 1724 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations