ppiab

ID

ZDB-GENE-030131-7459

Name

peptidylprolyl isomerase Ab (cyclophilin A)

Symbol

ppiab Nomenclature History

Previous Names

ppial
cyclophilin (1)
wu:fj18g05
zgc:73102
zgc:86688

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to hypoxia. Predicted to be located in extracellular region and nucleus. Predicted to be active in cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73102 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppiab Human Ortholog

No data available

Associated With ppiab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Domain	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Family	IPR024936	Cyclophilin-type peptidyl-prolyl cis-trans isomerase
Homologous_superfamily	IPR029000	Cyclophilin-like domain superfamily