Gene
fuca1.1
- ID
- ZDB-GENE-030131-7434
- Name
- alpha-L-fucosidase 1, tandem duplicate 1
- Symbol
- fuca1.1 Nomenclature History
- Previous Names
-
- fuca1
- wu:fj17c05
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to act upstream of or within carbohydrate metabolic process and lipid metabolic process. Predicted to be located in membrane. Predicted to be active in lysosome. Is expressed in several structures, including EVL; epidermis; periderm; sensory system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56379 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fucosidosis | Alliance | Fucosidosis | 230000 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018526 | Glycoside hydrolase, family 29, conserved site |
| Domain | IPR031919 | Alpha-L-fucosidase, C-terminal |
| Family | IPR000933 | Glycoside hydrolase, family 29 |
| Family | IPR016286 | Alpha-L-fucosidase, metazoa-type |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
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Domain Details Per Protein
| Protein | Length | Alpha-L-fucosidase, C-terminal | Alpha-L-fucosidase, metazoa-type | Glycoside hydrolase, family 29 | Glycoside hydrolase, family 29, conserved site | Glycoside hydrolase superfamily | Glycosyl hydrolase, all-beta |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZW80
|
451 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fuca1.1-201
(1)
|
Ensembl | 1,775 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-16J12 | ZFIN Curated Data | |
| Encodes | EST | fj17c05 | ||
| Encodes | cDNA | MGC:56379 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76962 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212740 (1) | 1700 nt | ||
| Genomic | GenBank:BX936306 (1) | 70278 nt | ||
| Polypeptide | UniProtKB:Q7ZW80 (1) | 451 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mercer, S., Odelberg, S.J., and Simon, H.G. (2013) A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Developmental Biology. 382(2):457-469
- Sharma, M.K., Saxena, V., Liu, R.Z., Thisse, C., Thisse, B., Denovan-Wright, E.M., and Wright, J.M. (2005) Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development. Gene expression patterns : GEP. 5(3):371-379
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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