Gene

wasb

ID
ZDB-GENE-030131-7098
Name
WASP actin nucleation promoting factor b
Symbol
wasb Nomenclature History
Previous Names
  • was
  • wasp1 (1)
  • wu:fk81c08
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Involved in macrophage chemotaxis; neutrophil chemotaxis; and regulation of neutrophil migration. Predicted to localize to actin cortical patch and actin filament. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Orthologous to human WAS (WASP actin nucleation promoting factor).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wasb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thrombocytopenia Alliance Thrombocytopenia, X-linked 313900
thrombocytopenia Alliance Thrombocytopenia, X-linked, intermittent 313900
Wiskott-Aldrich syndrome Alliance Wiskott-Aldrich syndrome 301000
Neutropenia, severe congenital, X-linked 300299
Associated With wasb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000095 CRIB domain
Domain IPR000697 WH1/EVH1 domain
Domain IPR003124 WH2 domain
Domain IPR033927 WASP family, EVH1 domain
Family IPR027641 Wiskott-Aldrich syndrome protein
Homologous_superfamily IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily PH-like domain superfamily WASP family, EVH1 domain WH1/EVH1 domain WH2 domain Wiscott-Aldrich syndrome protein, C-terminal Wiskott-Aldrich syndrome protein
UniProtKB:Q7T318 479
UniProtKB:B0S5G7 271
UniProtKB:B0S5G8 479
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations