Gene
fndc3a
- ID
- ZDB-GENE-030131-7015
- Name
- fibronectin type III domain containing 3A
- Symbol
- fndc3a Nomenclature History
- Previous Names
-
- wu:fk65b04
- zmp:0000001126
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within medial fin development. Predicted to be located in membrane. Is expressed in several structures, including brain; cloaca; median fin fold; notochord; and tail bud. Orthologous to human FNDC3A (fibronectin type III domain containing 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Liedtke et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 9 figures from Liedtke et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fndc3a | (3) | |
| CRISPR2-fndc3a | Liedtke et al., 2019 | |
| MO1-fndc3a | N/A | Liedtke et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PIB9 | InterPro | 1217 | ||||
| UniProtKB:A0A8M9PLA6 | InterPro | 1247 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fndc3a-201
(1)
|
Ensembl | 6,357 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021466300 (1) | 5246 nt | ||
| Genomic | GenBank:LO017655 (1) | 38726 nt | ||
| Polypeptide | UniProtKB:A0A8M9PLA6 (1) | 1247 aa |
- Liedtke, D., Klopocki, E. (2022) Microarray expression profiling of fndc3a zebrafish mutants. microPublication. Biology. 2022:
- Jia, Z., Zhao, C., Wang, M., Zhao, X., Zhang, W., Han, T., Xia, Q., Han, Z., Lin, R., Li, X. (2019) Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 121:109558
- Liedtke, D., Orth, M., Meissler, M., Geuer, S., Knaup, S., Köblitz, I., Klopocki, E. (2019) ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects. Scientific Reports. 9:13383
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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