Gene

mdm4

ID

ZDB-GENE-030131-6872

Name

MDM4 regulator of p53

Symbol

mdm4 Nomenclature History

Previous Names

wu:fa09h09
wu:fi33d10

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process and regulation of cell cycle. Predicted to be located in nucleus. Is expressed in post-vent region. Orthologous to human MDM4 (MDM4 regulator of p53).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:113995 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdm4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Bone marrow failure syndrome 6	618849

Associated With mdm4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001876	Zinc finger, RanBP2-type
Domain	IPR003121	SWIB/MDM2 domain
Family	IPR015458	MDM4
Family	IPR016495	p53 negative regulator Mdm2/Mdm4
Family	IPR051652	MDM2/MDM4 and MUL1
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily
Homologous_superfamily	IPR036885	SWIB/MDM2 domain superfamily