Gene
tafazzin
- ID
- ZDB-GENE-030131-684
- Name
- tafazzin, phospholipid-lysophospholipid transacylase
- Symbol
- tafazzin Nomenclature History
- Previous Names
-
- taz
- wu:fb39f12
- zgc:91803
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have O-acyltransferase activity. Involved in heart looping and positive regulation of heart contraction. Predicted to localize to integral component of mitochondrial outer membrane. Used to study Barth syndrome and visceral heterotaxy. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Is expressed in endoderm; head; immature eye; pericardial region; and post-vent region. Orthologous to human TAZ (tafazzin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909625 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Barth syndrome | Alliance | Barth syndrome | 302060 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Phospholipid/glycerol acyltransferase | Tafazzin |
|---|---|---|---|
|
UniProtKB:A0A8M3AV28
|
259 | ||
|
UniProtKB:F1QCP6
|
262 | ||
|
UniProtKB:A0A8M9PEW5
|
175 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
taz-202
(1)
|
Ensembl | 827 nt | ||
| aberrant processed transcript |
taz-208
(1)
|
Ensembl | 694 nt | ||
| mRNA |
taz-201
(1)
|
Ensembl | 2,736 nt | ||
| mRNA |
taz-203
(1)
|
Ensembl | 495 nt | ||
| mRNA |
taz-205
(1)
|
Ensembl | 1,824 nt | ||
| ncRNA |
taz-002
(1)
|
Ensembl | 918 nt | ||
| ncRNA |
taz-004
(1)
|
Ensembl | 1,158 nt | ||
| ncRNA |
taz-005
(1)
|
Ensembl | 908 nt |
Interactions and Pathways
No data available
Plasmids
No data available