Gene

picalmb

ID

ZDB-GENE-030131-6795

Name

phosphatidylinositol binding clathrin assembly protein b

Symbol

picalmb Nomenclature History

Previous Names

picalm
picalml
fa01d03
wu:fa01d03 (1)
wu:fa05d03
wu:fb69g01
wu:fe17e02
zgc:91993

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91993 (1 image)
IMAGE:6911564 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With picalmb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid, somatic	601626

Associated With picalmb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011417	AP180 N-terminal homology (ANTH) domain
Domain	IPR013809	ENTH domain
Family	IPR045192	Clathrin coat assembly protein AP180-like
Homologous_superfamily	IPR008942	ENTH/VHS
Homologous_superfamily	IPR014712	ANTH domain superfamily

Domain Details Per Protein

Protein	Length	ANTH domain superfamily	AP180 N-terminal homology (ANTH) domain	Clathrin coat assembly protein AP180-like	ENTH domain	ENTH/VHS
UniProtKB:A0A8M3APS6 InterPro	651
UniProtKB:Q6AXI5 InterPro	590
UniProtKB:A0A8M3B104 InterPro	701
UniProtKB:A0A8M6ZA05 InterPro	702
UniProtKB:A0A8M3APR9 InterPro	729
UniProtKB:A0A8M6Z9M1 InterPro	730
UniProtKB:A0A8M3B110 InterPro	616
UniProtKB:A0A8M3AHC4 InterPro	621
UniProtKB:A0A8M3ASP1 InterPro	672
UniProtKB:A0A8M3AIH0 InterPro	667
UniProtKB:A0A8M3AIG6 InterPro	700
UniProtKB:A0A8M3AHB8 InterPro	725
UniProtKB:A0A8M6Z2V9 InterPro	726
UniProtKB:A0A8M6Z4D6 InterPro	704

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	picalmb-203 (1) Ensembl	Ensembl	1,634 nt	Select Tool ZFIN BLAST
mRNA	picalmb-205 (1) Ensembl	Ensembl	4,903 nt	Select Tool ZFIN BLAST
mRNA	picalmb-206 (1) Ensembl	Ensembl	5,105 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-002 (1) Ensembl	Ensembl	627 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-003 (1) Ensembl	Ensembl	537 nt	Select Tool ZFIN BLAST
ncRNA	picalmb-004 (1) Ensembl	Ensembl	161 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations