Gene
vps41
- ID
- ZDB-GENE-030131-6671
- Name
- VPS41 subunit of HOPS complex
- Symbol
- vps41 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Involved in endosome to lysosome transport. Acts upstream of or within vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 29. Orthologous to human VPS41 (VPS41 subunit of HOPS complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Sanderson et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 29 | Alliance | Spinocerebellar ataxia, autosomal recessive 29 | 619389 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Family | IPR016902 | Vacuolar protein sorting-associated protein 41 |
| Family | IPR045111 | Vacuolar protein sorting-associated protein Vps41/Vps8 |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR000547 | Clathrin, heavy chain/VPS, 7-fold repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Clathrin, heavy chain/VPS, 7-fold repeat | Tetratricopeptide-like helical domain superfamily | Vacuolar protein sorting-associated protein 41 | Vacuolar protein sorting-associated protein Vps41/Vps8 | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13AB89 | InterPro | 854 | |||||||
| UniProtKB:E7F590 | InterPro | 854 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available