Gene

ddx46

ID

ZDB-GENE-030131-667

Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Symbol

ddx46 Nomenclature History

Previous Names

fb39a03
fj67d06
wu:fb39a03 (1)
wu:fj67d06

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and RNA helicase activity. Involved in several processes, including animal organ development; mRNA splicing, via spliceosome; and positive regulation of hemopoiesis. Predicted to localize to nucleus. Is expressed in brain; digestive system; head; hematopoietic system; and pectoral fin bud. Orthologous to human DDX46 (DEAD-box helicase 46).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx46 Human Ortholog

No data available

Associated With ddx46 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Family	IPR050079	DEAD box RNA helicase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase