Gene

psmc3

ID

ZDB-GENE-030131-666

Name

proteasome 26S subunit, ATPase 3

Symbol

psmc3 Nomenclature History

Previous Names

wu:fb39a02
zgc:86713 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable proteasome-activating activity. Involved in lens development in camera-type eye and semicircular canal fusion. Predicted to be located in cytoplasm and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in inner ear. Used to study cataract and sensorineural hearing loss. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6896890 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Kröll-Hermi et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Deafness, cataract, impaired intellectual development, and polyneuropathy	619354

Associated With psmc3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	WT + MO1-psmc3	standard conditions	Kröll-Hermi et al., 2020
cataract	WT + CRISPR2-psmc3	standard conditions	Kröll-Hermi et al., 2020
sensorineural hearing loss	WT + CRISPR2-psmc3	standard conditions	Kröll-Hermi et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR032501	Proteasomal ATPase, second OB domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR050221	26S Proteasome Regulatory ATPase
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	26S Proteasome Regulatory ATPase	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	Nucleic acid-binding, OB-fold	P-loop containing nucleoside triphosphate hydrolase	Proteasomal ATPase, second OB domain
UniProtKB:A0A0R4ILA8 InterPro	427
UniProtKB:A0A8M2BGA0 InterPro	425
UniProtKB:Q6IQL5 InterPro	404

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	psmc3-203 (1) Ensembl	Ensembl	508 nt	Select Tool ZFIN BLAST
mRNA	psmc3-201 (1) Ensembl	Ensembl	1,811 nt	Select Tool ZFIN BLAST
mRNA	psmc3-202 (1) Ensembl	Ensembl	1,554 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations