Gene
ubr5
- ID
- ZDB-GENE-030131-6559
- Name
- ubiquitin protein ligase E3 component n-recognin 5
- Symbol
- ubr5 Nomenclature History
- Previous Names
-
- edd1 (1)
- wu:fa16c12
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin-ubiquitin ligase activity. Predicted to be involved in several processes, including negative regulation of histone H2A K63-linked ubiquitination; positive regulation of canonical Wnt signaling pathway; and regulation of double-strand break repair. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000569 | HECT domain |
| Domain | IPR003126 | Zinc finger, UBR-type |
| Domain | IPR024725 | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain |
| Domain | IPR047503 | E3 ubiquitin-protein ligase UBR5, UBR-box |
| Homologous_superfamily | IPR009091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036053 | PABC (PABP) domain |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain | E3 ubiquitin-protein ligase UBR5, UBR-box | HECT domain | HECT, E3 ligase catalytic domain | PABC (PABP) domain | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Zinc finger, UBR-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P7S4
|
2828 | |||||||
|
UniProtKB:A0A8M1NV16
|
2794 | |||||||
|
UniProtKB:A0A8M9PJ96
|
2833 | |||||||
|
UniProtKB:A0A8M2B4T2
|
2816 | |||||||
|
UniProtKB:A0A8M9NZ45
|
2832 | |||||||
|
UniProtKB:A0A8M9PM86
|
2822 | |||||||
|
UniProtKB:A0A8M2B598
|
2822 | |||||||
|
UniProtKB:A0A8M9PJA4
|
2793 | |||||||
|
UniProtKB:A0A8M9PCY7
|
2827 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available