ZFIN is now using GRCz12tu for Genomic Data
Gene
eef1db
- ID
- ZDB-GENE-030131-6544
- Name
- eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
- Symbol
- eef1db Nomenclature History
- Previous Names
-
- im:7233939
- si:dkey-235d18.4
- wu:fa14f09
- zgc:114052
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language | Alliance | Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language | 621150 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001326 | Translation elongation factor EF1B, beta/delta chains, conserved site |
| Domain | IPR014038 | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
| Domain | IPR018940 | Elongation factor 1 beta central acidic region, eukaryote |
| Family | IPR049720 | Translation elongation factor EF1B, beta/delta subunit |
| Homologous_superfamily | IPR014717 | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
| Homologous_superfamily | IPR036219 | Translation elongation factor eEF-1beta-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Elongation factor 1 beta central acidic region, eukaryote | Translation elongation factor eEF-1beta-like superfamily | Translation elongation factor EF1B, beta/delta chains, conserved site | Translation elongation factor EF1B, beta/delta subunit | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7W1 | InterPro | 578 | ||||||
| UniProtKB:A0A8M2B7V6 | InterPro | 554 | ||||||
| UniProtKB:Q5SPD1 | InterPro | 274 | ||||||
| UniProtKB:Q5SPD0 | InterPro | 298 | ||||||
| UniProtKB:A0AC58I3M7 | InterPro | 274 | ||||||
| UniProtKB:A0AC58I3N8 | InterPro | 554 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eef1db-201
(1)
|
Ensembl | 1,042 nt | ||
| mRNA |
eef1db-202
(1)
|
Ensembl | 988 nt | ||
| mRNA |
eef1db-203
(1)
|
Ensembl | 830 nt | ||
| mRNA |
eef1db-204
(1)
|
Ensembl | 661 nt | ||
| mRNA |
eef1db-205
(1)
|
Ensembl | 661 nt | ||
| mRNA |
eef1db-206
(1)
|
Ensembl | 804 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers