Gene
eef1db
- ID
- ZDB-GENE-030131-6544
- Name
- eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein)
- Symbol
- eef1db Nomenclature History
- Previous Names
-
- im:7233939
- si:dkey-235d18.4
- wu:fa14f09
- zgc:114052
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language | 621150 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001326 | Translation elongation factor EF1B, beta/delta chains, conserved site |
| Domain | IPR014038 | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain |
| Domain | IPR018940 | Elongation factor 1 beta central acidic region, eukaryote |
| Family | IPR049720 | Translation elongation factor EF1B, beta/delta subunit |
| Homologous_superfamily | IPR014717 | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Elongation factor 1 beta central acidic region, eukaryote | Translation elongation factor eEF-1beta-like superfamily | Translation elongation factor EF1B, beta/delta chains, conserved site | Translation elongation factor EF1B, beta/delta subunit | Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain | Translation elongation factor EF1B/small ribosomal subunit protein bS6 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7W1 | InterPro | 578 | ||||||
| UniProtKB:A0A8M2B7V6 | InterPro | 554 | ||||||
| UniProtKB:Q5SPD1 | InterPro | 274 | ||||||
| UniProtKB:Q5SPD0 | InterPro | 298 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eef1db-201
(1)
|
Ensembl | 1,042 nt | ||
| mRNA |
eef1db-202
(1)
|
Ensembl | 988 nt | ||
| mRNA |
eef1db-203
(1)
|
Ensembl | 830 nt | ||
| mRNA |
eef1db-204
(1)
|
Ensembl | 661 nt | ||
| mRNA |
eef1db-205
(1)
|
Ensembl | 661 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-235D18 | ZFIN Curated Data | |
| Encodes | EST | fa14f09 | ||
| Encodes | EST | IMAGE:7146343 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7163240 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7233939 | ||
| Encodes | cDNA | MGC:114052 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162459 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001161414 (1) | 1081 nt | ||
| Genomic | GenBank:AL929003 (1) | 175099 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7W1 (1) | 578 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ozbudak, E.M., Tassy, O., and Pourquié, O. (2010) Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Proceedings of the National Academy of Sciences of the United States of America. 107(9):4224-4229
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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