Gene

prkcda

ID
ZDB-GENE-030131-6503
Name
protein kinase C, delta a
Symbol
prkcda Nomenclature History
Previous Names
  • prkcd
  • fb09d10
  • fv43b11
  • wu:fb09d10
  • wu:fv43b11
  • zgc:56558
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within apoptotic process and protein phosphorylation. Located in immunological synapse. Is expressed in blood; myotome; nervous system; otic vesicle; and somite. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkcda Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 3 Alliance Autoimmune lymphoproliferative syndrome, type III 615559
Associated With prkcda Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000008 C2 domain
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Domain IPR034667 Novel protein kinase C delta, catalytic domain
Family IPR014376 Protein kinase C, delta/epsilon/eta/theta types
Family IPR027436 Protein kinase C, delta
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR046349 C1-like domain superfamily
Domain Details Per Protein
Protein Additional Resources Length AGC-kinase, C-terminal C1-like domain superfamily C2 domain C2 domain superfamily Diacylglycerol/phorbol-ester binding Novel protein kinase C delta, catalytic domain Protein kinase, ATP binding site Protein kinase C, delta Protein kinase C, delta/epsilon/eta/theta types Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q7ZUC5 InterPro 684
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA prkcda-201 (1)
Ensembl
Ensembl 2,908 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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