Gene
map4k5
- ID
- ZDB-GENE-030131-6497
- Name
- mitogen-activated protein kinase kinase kinase kinase 5
- Symbol
- map4k5 Nomenclature History
- Previous Names
-
- fl74c10
- wu:fl74c10
- zgc:55719 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55719 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001180 | Citron homology (CNH) domain |
| Family | IPR021160 | Mitogen-activated protein (MAP) kinase kinase kinase kinase |
| Family | IPR050629 | STE20/SPS1-related Proline-Alanine-rich Kinase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Citron homology (CNH) domain | Mitogen-activated protein (MAP) kinase kinase kinase kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | STE20/SPS1-related Proline-Alanine-rich Kinase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A6G9 | InterPro | 878 | ||||||
| UniProtKB:Q7ZUA2 | InterPro | 878 | ||||||
| UniProtKB:A0A8M9QF91 | InterPro | 893 | ||||||
| UniProtKB:A0A8M9QJK1 | InterPro | 891 | ||||||
| UniProtKB:A0A8M2B3T3 | InterPro | 881 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map4k5-201
(1)
|
Ensembl | 3,735 nt | ||
| mRNA |
map4k5-202
(1)
|
Ensembl | 745 nt | ||
| ncRNA |
map4k5-003
(1)
|
Ensembl | 485 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-282C13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-69E12 | ZFIN Curated Data | |
| Encodes | EST | fl74c10 | ||
| Encodes | cDNA | MGC:55719 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55985 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199913 (1) | 3755 nt | ||
| Genomic | GenBank:BX936452 (1) | 136110 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q9K2 (1) | 894 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Liu, Y., Zhu, Z., Ho, I.H.T., Shi, Y., Li, J., Wang, X., Chan, M.T.V., Cheng, C.H.K. (2020) Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Frontiers in genetics. 11:853
- Pfeiffer, J., Tarbashevich, K., Bandemer, J., Palm, T., Raz, E. (2018) Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90. Developmental Biology. 436(2):84-93
- Tokarz, D.A., Heffelfinger, A.K., Jima, D.D., Gerlach, J., Shah, R.N., Rodriguez-Nunez, I., Kortum, A.N., Fletcher, A.A., Nordone, S.K., Law, J.M., Heber, S., Yoder, J.A. (2017) Disruption of Trim9 function abrogates macrophage motility in vivo. Journal of Leukocyte Biology. 102(6):1371-1380
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Lam, S.H., Mathavan, S., Parinov, S., and Gong, Z. (2011) A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish. Disease models & mechanisms. 4(6):801-13
- Fassier, C., Hutt, J.A., Scholpp, S., Lumsden, A., Giros, B., Nothias, F., Schneider-Maunoury, S., Houart, C., and Hazan, J. (2010) Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nature Neuroscience. 13(11):1380-1387
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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