Gene

map4k5

ID

ZDB-GENE-030131-6497

Name

mitogen-activated protein kinase kinase kinase kinase 5

Symbol

map4k5 Nomenclature History

Previous Names

fl74c10
wu:fl74c10
zgc:55719 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase kinase activity. Predicted to be involved in activation of protein kinase activity; intracellular signal transduction; and regulation of mitotic cell cycle. Predicted to localize to cytoplasm. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55719 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map4k5 Human Ortholog

No data available

Associated With map4k5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR021160	Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Citron homology (CNH) domain	Mitogen-activated protein (MAP) kinase kinase kinase kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	STE20/SPS1-related Proline-Alanine-rich Kinase
UniProtKB:B8A6G9 InterPro	878
UniProtKB:Q7ZUA2 InterPro	878
UniProtKB:A0A8M9QF91 InterPro	893
UniProtKB:A0A8M9QJK1 InterPro	891
UniProtKB:A0A8M2B3T3 InterPro	881
UniProtKB:A0A8M9QNA9 InterPro	892
UniProtKB:A0A8M9Q9K2 InterPro	894
UniProtKB:A0A8M2B328 InterPro	866

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map4k5-201 (1) Ensembl	Ensembl	3,735 nt	Select Tool
mRNA	map4k5-202 (1) Ensembl	Ensembl	745 nt	Select Tool
ncRNA	map4k5-003 (1) Ensembl	Ensembl	485 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations