Gene
st14a
- ID
- ZDB-GENE-030131-6496
- Name
- ST14 transmembrane serine protease matriptase a
- Symbol
- st14a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables molecular function activator activity and peptidase activity. Involved in protein processing. Acts upstream of or within cell population proliferation; epidermis development; and morphogenesis of an epithelium. Predicted to be located in membrane. Is expressed in epidermis; gut; lateral line primordium; otic vesicle; and primitive olfactory epithelium. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive congenital ichthyosis 11 | Alliance | Ichthyosis, congenital, autosomal recessive 11 | 602400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000082 | SEA domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR017051 | Peptidase S1A, matripase |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036364 | SEA domain superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | CUB domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Peptidase S1A, matripase | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | SEA domain | SEA domain superfamily | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1RLP8
|
827 | |||||||||||||
|
UniProtKB:A0A8M9P160
|
833 | |||||||||||||
|
UniProtKB:A0A8M1N8U6
|
834 | |||||||||||||
|
UniProtKB:A5PMY0
|
834 |
Interactions and Pathways
No data available
Plasmids
No data available