Gene

st14a

ID
ZDB-GENE-030131-6496
Name
ST14 transmembrane serine protease matriptase a
Symbol
st14a Nomenclature History
Previous Names
  • st14
  • mat1a (1)
  • matriptase 1a (1)
  • wu:fi41g07
  • wu:fl72f01
  • zgc:136950
  • zgc:152656
  • zgc:152657
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits peptidase activity. Involved in several processes, including epidermis development; morphogenesis of an epithelium; and protein processing. Predicted to localize to integral component of membrane. Is expressed in epidermis; gut; lateral line primordium; otic vesicle; and primitive olfactory epithelium. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With st14a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive congenital ichthyosis 11 Alliance Ichthyosis, congenital, autosomal recessive 11 602400
Associated With st14a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000082 SEA domain
Domain IPR000859 CUB domain
Domain IPR001254 Serine proteases, trypsin domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR017051 Peptidase S1A, matripase
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036364 SEA domain superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length CUB domain LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Peptidase S1A, chymotrypsin family Peptidase S1A, matripase Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold SEA domain SEA domain superfamily Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site Spermadhesin, CUB domain superfamily
UniProtKB:A3KP13 233
UniProtKB:Q1RLP8 827
UniProtKB:A5PMX9 191
UniProtKB:A5PMY0 834
UniProtKB:A1A5H5 826
UniProtKB:A5PMX8 77
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations