Gene
cap1
- ID
- ZDB-GENE-030131-6459
- Name
- CAP, adenylate cyclase-associated protein 1 (yeast)
- Symbol
- cap1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable actin monomer binding activity and adenylate cyclase binding activity. Acts upstream of or within mesodermal cell migration and somitogenesis. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in ectoderm; embryonic structure; heart; segmental plate; and skeletal muscle. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Daggett et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013992 | Adenylate cyclase-associated CAP, N-terminal |
| Conserved_site | IPR018106 | CAP, conserved site, N-terminal |
| Domain | IPR006599 | CARP motif |
| Domain | IPR013912 | Adenylate cyclase-associated CAP, C-terminal |
| Domain | IPR017901 | C-CAP/cofactor C-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylate cyclase-associated CAP | Adenylate cyclase-associated CAP, C-terminal | Adenylate cyclase-associated CAP, C-terminal superfamily | Adenylate cyclase-associated CAP, N-terminal | Adenylate cyclase-associated CAP, N-terminal domain superfamily | CAP, conserved site, N-terminal | CAP, N-terminal domain | CARP motif | C-CAP/cofactor C-like domain | Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6YBS2 | InterPro | 463 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-365B9 | ZFIN Curated Data | |
| Contains | SNP | rs3728993 | ZFIN Curated Data | |
| Contains | SNP | rs3728994 | ZFIN Curated Data | |
| Encodes | EST | fj98f01 | ||
| Encodes | cDNA | MGC:63872 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171388 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199909 (1) | 1726 nt | ||
| Genomic | GenBank:CU611043 (2) | 34732 nt | ||
| Polypeptide | UniProtKB:Q6YBS2 (1) | 463 aa |
- Akthar, I.S.T., Pichiah, P.B.T., Arunachalam, S., Raja, S. (2019) Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel-like factor4. Journal of biochemical and molecular toxicology. :e22235
- Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Effendi, K., Yamazaki, K., Mori, T., Masugi, Y., Makino, S., and Sakamoto, M. (2013) Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression. Experimental cell research. 319(1):35-44
- Singh, S.K., Sethi, S., Aravamudhan, S., Krüger, M., and Grabher, C. (2013) Proteome mapping of adult zebrafish marrow neutrophils reveals partial cross species conservation to human peripheral neutrophils. PLoS One. 8(9):e73998
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
- Daggett, D.F., Domingo, C.R., Currie, P.D., and Amacher, S.L. (2007) Control of morphogenetic cell movements in the early zebrafish myotome. Developmental Biology. 309(2):169-179
- Gardiner, M.R., Daggett, D.F., Zon, L.I., and Perkins, A.C. (2005) Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(4):992-996
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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