toporsa

ID

ZDB-GENE-030131-6401

Name

topoisomerase I binding, arginine/serine-rich a

Symbol

toporsa Nomenclature History

Previous Names

topors
si:ch211-145b13.4
wu:fc21e07 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of apoptotic process and photoreceptor cell development. Acts upstream of or within retina layer formation. Predicted to be located in photoreceptor connecting cilium. Is expressed in photoreceptor inner segment layer; retinal ganglion cell layer; retinal inner nuclear layer; and retinal outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chakarova et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Chakarova et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With toporsa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 31	Alliance	Retinitis pigmentosa 31	609923

Associated With toporsa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type