Gene

cdk5rap2

ID

ZDB-GENE-030131-6392

Name

CDK5 regulatory subunit associated protein 2

Symbol

cdk5rap2 Nomenclature History

Previous Names

cep215 (1)
fi74c05
wu:fi74c05
zgc:55582

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable molecular adaptor activity. Predicted to be involved in centrosome cycle; positive regulation of microtubule nucleation; and regulation of Golgi organization. Predicted to be located in cytoplasm and microtubule organizing center. Predicted to be active in Golgi apparatus and centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to human CDK5RAP2 (CDK5 regulatory subunit associated protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55582 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdk5rap2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 3	Alliance	Microcephaly 3, primary, autosomal recessive	604804

Associated With cdk5rap2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR012943	Centrosomin, N-terminal motif 1
Family	IPR052593	Microtubule-associated AKAP9-binding protein

Domain Details Per Protein

Protein	Length	Centrosomin, N-terminal motif 1	Microtubule-associated AKAP9-binding protein
UniProtKB:A0A8M3ALW0 InterPro	2873
UniProtKB:A0A8M3AWK4 InterPro	2871
UniProtKB:A0A8M3AL71 InterPro	2912
UniProtKB:A0A8M3ATJ9 InterPro	2913
UniProtKB:Q802Z7 InterPro	1208
UniProtKB:A0A8M3ATK8 InterPro	2866
UniProtKB:A0A8M3AL75 InterPro	2841
UniProtKB:A0A8M3B4F9 InterPro	2878