Gene

zmpste24

ID
ZDB-GENE-030131-6312
Name
zinc metallopeptidase, STE24 homolog
Symbol
zmpste24 Nomenclature History
Previous Names
  • fi45a02
  • wu:fi45a02
  • zgc:55655 (1)
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to localize to integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in connective tissue disease and lethal restrictive dermopathy. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zmpste24 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lethal restrictive dermopathy Alliance Restrictive dermopathy, lethal 275210
Mandibuloacral dysplasia with type B lipodystrophy 608612
Associated With zmpste24 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001915 Peptidase M48
Domain IPR032456 CAAX prenyl protease 1, N-terminal
Family IPR027057 CAAX prenyl protease 1
Domain Details Per Protein
Protein Length CAAX prenyl protease 1 CAAX prenyl protease 1, N-terminal Peptidase M48
UniProtKB:B2GS23 468
UniProtKB:Q802Z1 468
UniProtKB:F1QX19 468
UniProtKB:Q1LYB5 468
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations