Gene
yars2
- ID
- ZDB-GENE-030131-6268
- Name
- tyrosyl-tRNA synthetase 2, mitochondrial
- Symbol
- yars2 Nomenclature History
- Previous Names
-
- fi41d10
- wu:fi41d10
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation. Predicted to act upstream of or within tyrosyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myopathy, lactic acidosis, and sideroblastic anemia 2 | Alliance | Myopathy, lactic acidosis, and sideroblastic anemia 2 | 613561 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
| Family | IPR002307 | Tyrosine-tRNA ligase |
| Family | IPR024088 | Tyrosine-tRNA ligase, bacterial-type |
| Family | IPR024107 | Tyrosine-tRNA ligase, bacterial-type, type 1 |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036986 | RNA-binding S4 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class Ic | Aminoacyl-tRNA synthetase, class I, conserved site | RNA-binding S4 domain superfamily | Rossmann-like alpha/beta/alpha sandwich fold | Tyrosine-tRNA ligase | Tyrosine-tRNA ligase, bacterial-type | Tyrosine-tRNA ligase, bacterial-type, type 1 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PUY4 | InterPro | 309 | |||||||
| UniProtKB:F1Q4R5 | InterPro | 474 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000056263
(1)
|
Ensembl | 712 nt | ||
| mRNA |
yars2-201
(1)
|
Ensembl | 1,794 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-353B21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-218P2 | ZFIN Curated Data | |
| Encodes | EST | fi41d10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143920 (1) | 1906 nt | ||
| Genomic | GenBank:CR354430 (1) | 197231 nt | ||
| Polypeptide | UniProtKB:F1Q4R5 (1) | 474 aa |
- Jin, X., Zhang, Z., Nie, Z., Wang, C., Meng, F., Yi, Q., Chen, M., Sun, J., Zou, J., Jiang, P., Guan, M.X. (2021) An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function. The Journal of biological chemistry. 296:100437
- Chen, D., Zhang, Z., Chen, C., Yao, S., Yang, Q., Li, F., He, X., Ai, C., Wang, M., Guan, M.X. (2019) Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Nucleic acids research. 47(10):5341-5355
- Zhang, Q., Zhang, L., Chen, D., He, X., Yao, S., Zhang, Z., Chen, Y., Guan, M.X. (2018) Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function. Nucleic acids research. 46(20):10930-10945
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