Gene

yars2

ID

ZDB-GENE-030131-6268

Name

tyrosyl-tRNA synthetase 2, mitochondrial

Symbol

yars2 Nomenclature History

Previous Names

fi41d10
wu:fi41d10

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have tyrosine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myopathy, lactic acidosis, and sideroblastic anemia 2	Alliance	Myopathy, lactic acidosis, and sideroblastic anemia 2	613561

Associated With yars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002307	Tyrosine-tRNA ligase
Family	IPR024088	Tyrosine-tRNA ligase, bacterial-type
Family	IPR024107	Tyrosine-tRNA ligase, bacterial-type, type 1
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036986	RNA-binding S4 domain superfamily