ZFIN is now using GRCz12tu for Genomic Data
Gene
agk
- ID
- ZDB-GENE-030131-6202
- Name
- acylglycerol kinase
- Symbol
- agk Nomenclature History
- Previous Names
-
- fi38e09
- mulk
- wu:fi38e09
- zgc:55462 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP-dependent diacylglycerol kinase activity; acylglycerol kinase activity; and ceramide kinase activity. Predicted to be involved in ceramide biosynthetic process; protein insertion into mitochondrial inner membrane; and sphingosine biosynthetic process. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in mitochondrion and plasma membrane. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55462 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 38 | Alliance | Cataract 38, autosomal recessive | 614691 |
| Sengers syndrome | Alliance | Sengers syndrome | 212350 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR045579 | Acylglycerol kinase, C-terminal |
| Family | IPR050187 | Lipid Phosphate Formation and Regulation |
| Homologous_superfamily | IPR016064 | NAD kinase/diacylglycerol kinase-like domain superfamily |
| Homologous_superfamily | IPR017438 | Inorganic polyphosphate/ATP-NAD kinase, N-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | Acylglycerol kinase, C-terminal | Diacylglycerol kinase, catalytic domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | Lipid Phosphate Formation and Regulation | NAD kinase/diacylglycerol kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZW00 | InterPro | 422 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers