Gene
brd3a
- ID
- ZDB-GENE-030131-6141
- Name
- bromodomain containing 3a
- Symbol
- brd3a Nomenclature History
- Previous Names
-
- brd3
- fc01d09
- fc74a08
- fi36b10
- wu:fa13h06
- wu:fc01d09
- wu:fc74a08
- wu:fi04h10
- wu:fi36b10
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable lysine-acetylated histone binding activity. Acts upstream of or within thrombocyte differentiation. Predicted to be active in chromatin and nucleus. Orthologous to human BRD3 (bromodomain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Bielczyk-Maczy?ska et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021848Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37272 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45732 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-brd3a | Keatinge et al., 2021 | |
| MO1-brd3a | N/A | Bielczyk-Maczyńska et al., 2014 |
| MO2-brd3a | N/A | Bielczyk-Maczyńska et al., 2014 |
| MO3-brd3a | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B853 | InterPro | 660 | ||||||||
| UniProtKB:A0A8M2B828 | InterPro | 678 | ||||||||
| UniProtKB:A0A8M2B838 | InterPro | 682 | ||||||||
| UniProtKB:F1QQP6 | InterPro | 683 | ||||||||
| UniProtKB:A0A8M2B835 | InterPro | 655 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-182I17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-279C20 | ZFIN Curated Data | |
| Contains | SNP | rs3729096 | ZFIN Curated Data | |
| Contains | SNP | rs3729097 | ZFIN Curated Data | |
| Contains | SNP | rs3729098 | ZFIN Curated Data | |
| Contains | SNP | rs3729099 | ZFIN Curated Data | |
| Encodes | EST | fa13h06 | ||
| Encodes | EST | fc01d09 | ||
| Encodes | EST | fc74a08 | ||
| Encodes | EST | fi04h10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123389 (1) | 4247 nt | ||
| Genomic | GenBank:CR450799 (1) | 143672 nt | ||
| Polypeptide | UniProtKB:F1QQP6 (1) | 683 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
- Zhang, Y., O'Leary, M.N., Peri, S., Wang, M., Zha, J., Melov, S., Kappes, D.J., Feng, Q., Rhodes, J., Amieux, P.S., Morris, D.R., Kennedy, B.K., Wiest, D.L. (2017) Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Reports. 18:545-556
- Ko, S., Choi, T.Y., Russell, J.O., So, J., Monga, S.P., Shin, D. (2016) Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. Journal of hepatology. 64(2):316-25
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bielczyk-Maczyńska, E., Serbanovic-Canic, J., Ferreira, L., Soranzo, N., Stemple, D.L., Ouwehand, W.H., Cvejic, A. (2014) A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. PLoS Genetics. 10:e1004450
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hoffman, G.G., Branam, A.M., Huang, G., Pelegri, F., Cole, W.G., Wenstrup, R.M., and Greenspan, D.S. (2010) Characterization of the Six Zebrafish Clade B Fibrillar Procollagen Genes, with Evidence for Evolutionarily Conserved Alternative Splicing within the pro-alpha1(V) C-propeptide. Matrix biology : journal of the International Society for Matrix Biology. 29(4):261-275
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