Gene
aldh7a1
- ID
- ZDB-GENE-030131-6129
- Name
- aldehyde dehydrogenase 7 family, member A1
- Symbol
- aldh7a1 Nomenclature History
- Previous Names
-
- ATQ (1)
- wu:fi34d12
- wu:fi35e06
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits alpha-aminoadipate acetyltransferase activity. Involved in camera-type eye development; cartilage development; and pectoral fin development. Used to study epilepsy. Is expressed in several structures, including alar plate midbrain region; fin bud; musculature system; nervous system; and pharyngeal arch. Orthologous to human ALDH7A1 (aldehyde dehydrogenase 7 family member A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55319 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| early-onset vitamin B6-dependent epilepsy 4 | Alliance | Epilepsy, early-onset, 4, vitamin B6-dependent | 266100 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| pyridoxine-dependent epilepsy | aldh7a1zf2074/zf2074 | standard conditions | (2) |
| epilepsy | aldh7a1ot100/ot100 | standard conditions | Pena et al., 2017 |
| epilepsy | aldh7a1zf2074/zf2074 | standard conditions | Zabinyakov et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Family | IPR044638 | Aldehyde dehydrogenase family 7 member A1-like |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
| Homologous_superfamily | IPR016163 | Aldehyde dehydrogenase, C-terminal |
Domain Details Per Protein
| Protein | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase family 7 member A1-like | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q803R9
|
511 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh7a1-201
(1)
|
Ensembl | 1,899 nt |
Interactions and Pathways
No data available
Plasmids
No data available