Gene

mknk2a

ID

ZDB-GENE-030131-6099

Name

MAPK interacting serine/threonine kinase 2a

Symbol

mknk2a Nomenclature History

Previous Names

fi34c11
wu:fi34c11
wu:fi41e12
zgc:55587

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in lens; tail bud; and yolk syncytial layer. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55587 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mknk2a Human Ortholog

No data available

Associated With mknk2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050205	Calcium-dependent Serine/Threonine Protein Kinases
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Calcium-dependent Serine/Threonine Protein Kinases	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M9PT26 InterPro	240
UniProtKB:Q7ZVV9 InterPro	472

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mknk2a-201 (1) Ensembl	Ensembl	3,491 nt	Select Tool ZFIN BLAST
mRNA	mknk2a-204 (1) Ensembl	Ensembl	1,452 nt	Select Tool ZFIN BLAST
ncRNA	mknk2a-002 (1) Ensembl	Ensembl	784 nt	Select Tool ZFIN BLAST
ncRNA	mknk2a-003 (1) Ensembl	Ensembl	1,009 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations