Gene
ldb3b
- ID
- ZDB-GENE-030131-6032
- Name
- LIM domain binding 3b
- Symbol
- ldb3b Nomenclature History
- Previous Names
-
- ldb3l
- wu:fi31d08
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Is expressed in cardiovascular system; musculature system; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55814 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018168Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa42038 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1C | Alliance | Cardiomyopathy, dilated, 1C, with or without LVNC | 601493 |
| dilated cardiomyopathy 1C | Alliance | Cardiomyopathy, hypertrophic, 24 | 601493 |
| dilated cardiomyopathy 1C | Alliance | Left ventricular noncompaction 3 | 601493 |
| myofibrillar myopathy 4 | Alliance | Myopathy, myofibrillar, 4 | 609452 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PDZ and LIM domain-containing | PDZ and LIM domain protein 1-4/Zasp-like, middle domain | PDZ domain | PDZ superfamily | Zasp-like motif |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q802V0 | InterPro | 292 | |||||
| UniProtKB:A0A8M2B2Z1 | InterPro | 308 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ldb3b-201
(1)
|
Ensembl | 733 nt | ||
| mRNA |
ldb3b-202
(1)
|
Ensembl | 948 nt | ||
| mRNA |
ldb3b-205
(1)
|
Ensembl | 1,655 nt | ||
| mRNA |
ldb3b-206
(1)
|
Ensembl | 916 nt | ||
| mRNA |
ldb3b-207
(1)
|
Ensembl | 3,150 nt | ||
| mRNA |
ldb3b-208
(1)
|
Ensembl | 2,993 nt | ||
| ncRNA |
ldb3b-003
(1)
|
Ensembl | 835 nt | ||
| ncRNA |
ldb3b-005
(1)
|
Ensembl | 761 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103O20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-135B5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-214G6 | ZFIN Curated Data | |
| Encodes | EST | fi31d08 | ||
| Encodes | cDNA | MGC:55814 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77662 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199858 (1) | 1738 nt | ||
| Genomic | GenBank:CR854941 (2) | 204953 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2Z1 (1) | 308 aa |
- Kotani, Y., Morito, D., Yamazaki, S., Ogino, K., Kawakami, K., Takashima, S., Hirata, H., Nagata, K. (2015) Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213. Scientific Reports. 5:16161
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
- Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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