Gene

ldb3b

ID

ZDB-GENE-030131-6032

Name

LIM domain binding 3b

Symbol

ldb3b Nomenclature History

Previous Names

ldb3l
wu:fi31d08

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to localize to Z disc; actin cytoskeleton; and adherens junction. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Is expressed in cardiovascular system; musculature system; and somite. Orthologous to human LDB3 (LIM domain binding 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55814 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ldb3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1C	Alliance	Cardiomyopathy, dilated, 1C, with or without LVNC	601493
dilated cardiomyopathy 1C	Alliance	Cardiomyopathy, hypertrophic, 24	601493
dilated cardiomyopathy 1C	Alliance	Left ventricular noncompaction 3	601493
myofibrillar myopathy 4	Alliance	Myopathy, myofibrillar, 4	609452

Associated With ldb3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001478	PDZ domain
Domain	IPR006643	Zasp-like motif
Domain	IPR031847	PDZ and LIM domain protein 1-4/Zasp-like, middle domain
Family	IPR050604	PDZ and LIM domain-containing
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	PDZ and LIM domain-containing	PDZ and LIM domain protein 1-4/Zasp-like, middle domain	PDZ domain	PDZ superfamily	Zasp-like motif
UniProtKB:Q802V0 InterPro	292
UniProtKB:A0A8M2B2Z1 InterPro	308

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ldb3b-201 (1) Ensembl	Ensembl	733 nt	Select Tool
mRNA	ldb3b-202 (1) Ensembl	Ensembl	948 nt	Select Tool
mRNA	ldb3b-205 (1) Ensembl	Ensembl	1,655 nt	Select Tool
mRNA	ldb3b-206 (1) Ensembl	Ensembl	916 nt	Select Tool
mRNA	ldb3b-207 (1) Ensembl	Ensembl	3,150 nt	Select Tool ZFIN BLAST
mRNA	ldb3b-208 (1) Ensembl	Ensembl	2,993 nt	Select Tool ZFIN BLAST
ncRNA	ldb3b-003 (1) Ensembl	Ensembl	835 nt	Select Tool
ncRNA	ldb3b-005 (1) Ensembl	Ensembl	761 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations