Gene

rnf168

ID
ZDB-GENE-030131-6013
Name
ring finger protein 168
Symbol
rnf168 Nomenclature History
Previous Names
  • fi30d02
  • wu:fi30d02
  • zgc:64185 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to nucleus; site of double-strand break; and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rnf168 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
RIDDLE syndrome Alliance RIDDLE syndrome 611943
Associated With rnf168 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Family IPR034725 E3 ubiquitin-protein ligase RNF168
Family IPR051657 RNF168/RNF169 E3 ubiquitin-protein ligase
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase RNF168 RNF168/RNF169 E3 ubiquitin-protein ligase Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:A0A8M9Q066 474
UniProtKB:Q7T308 474
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA rnf168-201 (1) Ensembl 5,619 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations