Gene

smarca2

ID
ZDB-GENE-030131-5964
Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Symbol
smarca2 Nomenclature History
Previous Names
  • wu:fa56c07
  • wu:fi27f11
  • zgc:66238
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable ATPase, acting on DNA and DNA binding activity. Predicted to be involved in ATP-dependent chromatin remodeling and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin remodeling and regulation of transcription, DNA-templated. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Is expressed in liver and pronephric duct. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Laue et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smarca2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Blepharophimosis-impaired intellectual development syndrome 619293
Nicolaides-Baraitser syndrome 601358
Associated With smarca2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR000330 SNF2-related domain
Domain IPR001487 Bromodomain
Domain IPR001650 Helicase, C-terminal
Domain IPR006576 BRK domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014012 Helicase/SANT-associated domain
Domain IPR014978 Glutamine-Leucine-Glutamine, QLQ
Domain IPR029295 Snf2, ATP coupling domain
Family IPR030088 SWI/SNF complex subunit SMARCA2
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR037259 BRK domain superfamily
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRK domain BRK domain superfamily Bromodomain Bromodomain, conserved site Bromodomain-like superfamily Glutamine-Leucine-Glutamine, QLQ Helicase, C-terminal Helicase/SANT-associated domain Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase Snf2, ATP coupling domain SNF2-like, N-terminal domain superfamily SNF2-related domain SWI/SNF complex subunit SMARCA2
UniProtKB:A0A2R8QHR6 1562
UniProtKB:Q7ZWF7 567
UniProtKB:A0A0R4IJ25 1604
UniProtKB:F6NTB4 258
UniProtKB:A0A2R8QPC0 1566
UniProtKB:Q6P9P2 1568
UniProtKB:F6PBX5 170
UniProtKB:Q1MTE3 1568
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations