Gene

smarca2

ID

ZDB-GENE-030131-5964

Name

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2

Symbol

smarca2 Nomenclature History

Previous Names

wu:fa56c07
wu:fi27f11
zgc:66238

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin remodeling and regulation of DNA-templated transcription. Predicted to be part of SWI/SNF complex. Predicted to be active in nucleus. Is expressed in liver and pronephric duct. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66238 (10 images)
IMAGE:7157675 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Laue et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smarca2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
blepharophimosis-impaired intellectual development syndrome	Alliance	Blepharophimosis-impaired intellectual development syndrome	619293
Nicolaides-Baraitser syndrome	Alliance	Nicolaides-Baraitser syndrome	601358

Associated With smarca2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR000330	SNF2, N-terminal
Domain	IPR001487	Bromodomain
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR006576	BRK domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014012	Helicase/SANT-associated domain
Domain	IPR014978	Glutamine-Leucine-Glutamine, QLQ
Domain	IPR029295	Snf2, ATP coupling domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR037259	BRK domain superfamily
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	BRK domain	BRK domain superfamily	Bromodomain	Bromodomain, conserved site	Bromodomain-like superfamily	Glutamine-Leucine-Glutamine, QLQ	Helicase, C-terminal domain-like	Helicase/SANT-associated domain	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	Snf2, ATP coupling domain	SNF2-like, N-terminal domain superfamily	SNF2, N-terminal	SNF2/RAD5-like, C-terminal helicase domain
UniProtKB:Q1MTE3 InterPro	1568
UniProtKB:A0A8M3ASL9 InterPro	1578

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smarca2-201 (1) Ensembl	Ensembl	6,051 nt	Select Tool ZFIN BLAST
mRNA	smarca2-202 (1) Ensembl	Ensembl	823 nt	Select Tool ZFIN BLAST
mRNA	smarca2-203 (1) Ensembl	Ensembl	663 nt	Select Tool ZFIN BLAST
mRNA	smarca2-204 (1) Ensembl	Ensembl	4,830 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations