Gene
mkrn4
- ID
- ZDB-GENE-030131-5954
- Name
- makorin, ring finger protein, 4
- Symbol
- mkrn4 Nomenclature History
- Previous Names
-
- fi27c05
- si:ch73-237c6.4
- wu:fi27c05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within protein polyubiquitination. Is expressed in several structures, including eye; gill; gonad; integument; and liver. Orthologous to human MKRN6P (makorin ring finger protein 6, pseudogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Bohne et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mz42 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| mz44 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| mz45 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| mz75 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa16544 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27197 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ligase, CCCH-type zinc finger | MKRN-like | Zinc finger, CCCH-type | Zinc finger, CCCH-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BED9 | InterPro | 402 | |||||||
| UniProtKB:A9C4A6 | InterPro | 397 | |||||||
| UniProtKB:A0A8M9QDS1 | InterPro | 284 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-237C6 | ZFIN Curated Data | |
| Encodes | EST | fi27c05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128336 (1) | 1845 nt | ||
| Genomic | GenBank:CU302443 (1) | 43687 nt | ||
| Polypeptide | UniProtKB:A0A8M2BED9 (1) | 402 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bohne, A., Darras, A., D'Cotta, H., Baroiller, J.F., Galiana-Arnoux, D., and Volff, J.N. (2010) The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. BMC Genomics. 11:721
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