Gene
brdt
- ID
- ZDB-GENE-030131-5928
- Name
- bromodomain, testis-specific
- Symbol
- brdt Nomenclature History
- Previous Names
-
- fi25h02
- si:dkeyp-85h7.3
- wu:fi25h02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable histone reader activity and lysine-acetylated histone binding activity. Predicted to be involved in several processes, including male meiosis I; regulation of gene expression; and sperm DNA condensation. Predicted to act upstream of or within with a positive effect on positive regulation of gene expression. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159282 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-brdt | N/A | Huang et al., 2013 |
| MO2-brdt | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 21 | Alliance | ?Spermatogenic failure 21 | 617644 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | Bromodomain protein 4, C-terminal | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IJ54 | InterPro | 979 | |||||||||
| UniProtKB:I3IS77 | InterPro | 1093 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-85H7 | ZFIN Curated Data | |
| Contains | SNP | rs3727970 | ZFIN Curated Data | |
| Contains | SNP | rs3727971 | ZFIN Curated Data | |
| Encodes | EST | fi25h02 | ||
| Encodes | EST | IMAGE:2644102 | ||
| Encodes | EST | IMAGE:7159282 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001305664 (1) | 4960 nt | ||
| Genomic | GenBank:CU137682 (1) | 205390 nt | ||
| Polypeptide | UniProtKB:I3IS77 (1) | 1093 aa |
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Sarasquete, C., Úbeda-Manzanaro, M., Ortiz-Delgado, J.B. (2018) Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 211:57-67
- Ren, L., Tan, X.J., Xiong, Y.F., Xu, K., Zhou, Y., Zhong, H., Liu, Y., Hong, Y., Liu, S.J. (2014) Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Gene. 552(2):265-71
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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