ZFIN is now using GRCz12tu for Genomic Data
Gene
brdt
- ID
- ZDB-GENE-030131-5928
- Name
- bromodomain, testis-specific
- Symbol
- brdt Nomenclature History
- Previous Names
-
- fi25h02
- si:dkeyp-85h7.3
- wu:fi25h02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone reader activity and lysine-acetylated histone binding activity. Predicted to be involved in several processes, including male meiosis I; regulation of gene expression; and sperm DNA condensation. Predicted to act upstream of or within with a positive effect on positive regulation of gene expression. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159282 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 21 | Alliance | ?Spermatogenic failure 21 | 617644 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR027353 | NET domain |
| Domain | IPR031354 | Bromodomain protein 4, C-terminal |
| Domain | IPR043508 | Brdt, bromodomain, repeat I |
| Domain | IPR043509 | Brdt, bromodomain, repeat II |
| Family | IPR050935 | Bromodomain-containing chromatin reader |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR038336 | NET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Brdt, bromodomain, repeat I | Brdt, bromodomain, repeat II | Bromodomain | Bromodomain, conserved site | Bromodomain-containing chromatin reader | Bromodomain-like superfamily | Bromodomain protein 4, C-terminal | NET domain | NET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IJ54 | InterPro | 979 | |||||||||
| UniProtKB:I3IS77 | InterPro | 1093 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers