Gene

xpo6

ID

ZDB-GENE-030131-5912

Name

exportin 6

Symbol

xpo6 Nomenclature History

Previous Names

fi24f12
Ranbp20
wu:fi24f12

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable nuclear export signal receptor activity and small GTPase binding activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in cytoplasm and nucleus. Orthologous to human XPO6 (exportin 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55236 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa19963	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa33111	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa33112	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa33113	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With xpo6 Human Ortholog

No data available

Associated With xpo6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001494	Importin-beta, N-terminal domain
Domain	IPR013598	Exportin-1/Importin-beta-like
Family	IPR040016	Exportin-6
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold

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Domain Details Per Protein

Protein	Additional Resources	Length	Armadillo-like helical	Armadillo-type fold	Exportin-1/Importin-beta-like	Exportin-6	Importin-beta, N-terminal domain
UniProtKB:Q8QHJ8	InterPro	1128

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 3

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	xpo6-201 (1) Ensembl	Ensembl		469 nt	Select Tool ZFIN BLAST
mRNA	xpo6-202 (1) Ensembl	Ensembl		3,834 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-253E22	CT961050	ZFIN Curated Data
Contained in	BAC	DKEY-282H22	CR855387	ZFIN Curated Data
Contains	SNP	rs3728150		ZFIN Curated Data
Contains	SNP	rs3728151		ZFIN Curated Data
Encodes	EST	fi24f12	AW153700 AW154268
Encodes	cDNA	MGC:55236	BC044132	ZFIN Curated Data
Has Artifact	cDNA	MGC:92551	BC076072	ZFIN Curated Data
Has Artifact	cDNA	MGC:165439	BC142791	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_194374 (1)	4414 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL929124 (1)	165243 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q8QHJ8 (1)	1128 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	XPO6	16	Ensembl:ENSG00000169180 Gene:23214 HGNC:19733 OMIM:608411	Amino acid sequence comparison (1)
Mouse	Xpo6	7	Ensembl:ENSMUSG00000000131 Gene:74204 MGI:2429950	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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