Gene
ptpn11a
- ID
- ZDB-GENE-030131-5911
- Name
- protein tyrosine phosphatase non-receptor type 11a
- Symbol
- ptpn11a Nomenclature History
- Previous Names
-
- ptpn11
- fa14b09
- shp2 (1)
- wu:fa14b09
- wu:fi24f03
- zgc:55388
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits protein tyrosine phosphatase activity. Involved in several processes, including MAPK cascade; convergent extension involved in axis elongation; and embryonic morphogenesis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including LEOPARD syndrome (multiple); Noonan syndrome (multiple); juvenile myelomonocytic leukemia; metachondromatosis; and tetralogy of Fallot. Is expressed in blastoderm; blastomere; and head. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55388 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| juvenile myelomonocytic leukemia | Alliance | Leukemia, juvenile myelomonocytic, somatic | 607785 |
| metachondromatosis | Alliance | Metachondromatosis | 156250 |
| Noonan syndrome 1 | Alliance | Noonan syndrome 1 | 163950 |
| Noonan syndrome with multiple lentigines 1 | Alliance | LEOPARD syndrome 1 | 151100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Family | IPR012152 | Protein-tyrosine phosphatase, non-receptor type-6, -11 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-6, -11 | SH2 domain | SH2 domain superfamily | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZW17
|
594 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn11a-201
(1)
|
Ensembl | 3,923 nt | ||
| mRNA |
ptpn11a-202
(1)
|
Ensembl | 7,078 nt |
Interactions and Pathways
Plasmids
No data available