Gene
gclm
- ID
- ZDB-GENE-030131-5906
- Name
- glutamate-cysteine ligase, modifier subunit
- Symbol
- gclm Nomenclature History
- Previous Names
-
- GLCLR (1)
- id:ibd3182
- wu:fi24c07
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907712 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
zf3511 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Myocardial infarction, susceptibility to} | 608446 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Glutamate--cysteine ligase regulatory subunit | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily |
---|---|---|---|---|
UniProtKB:A0A8M3AUZ9
|
274 | |||
UniProtKB:Q803D0
|
273 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-7O6 | ZFIN Curated Data | |
Contains | SNP | rs3728145 | ZFIN Curated Data | |
Contains | SNP | rs3728146 | ZFIN Curated Data | |
Encodes | EST | fi24c07 | ||
Encodes | EST | ibd3182 | Kudoh et al., 2001 | |
Encodes | EST | IMAGE:6907712 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:55903 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199845 (1) | 1844 nt | ||
Genomic | GenBank:BX005425 (1) | 252440 nt | ||
Polypeptide | UniProtKB:A0A8M3AUZ9 (1) | 274 aa |
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542
- Li, X., Gao, D., Paudel, Y.N., Li, X., Zheng, M., Liu, G., Ma, Y., Chu, L., He, F., Jin, M. (2022) Anti-Parkinson's Disease Activity of Sanghuangprous vaninii Extracts in the MPTP-Induced Zebrafish Model. ACS Chemical Neuroscience. 13(3):330-339
- Üstündağ, F.D., Ünal, İ., Üstündağ, Ü.V., Cansız, D., Beler, M., Karagöz, A., Kara Subaşat, H., Alturfan, A.A., Mega Tiber, P., Emekli-Alturfan, E. (2022) 3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos. Neurochemical research. 47(6):1553-1564
- Cahill, T., da Silveira, W.A., Renaud, L., Williamson, T., Wang, H., Chung, D., Overton, I., Chan, S.S.L., Hardiman, G. (2021) Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cells. 10(4):
- Chen, J., Chen, Y., Zheng, Y., Zhao, J., Yu, H., Zhu, J., Li, D. (2021) Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro. Molecules. 26(18):
- Chen, J., Chen, Y., Zheng, Y., Zhao, J., Yu, H., Zhu, J., Li, D. (2021) Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo. Molecules. 26(10):
- Ji, X., Wang, B., Paudel, Y.N., Li, Z., Zhang, S., Mou, L., Liu, K., Jin, M. (2021) Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences. 8:655549
- Li, X., Alhasani, R.H., Cao, Y., Zhou, X., He, Z., Zeng, Z., Strang, N., Shu, X. (2021) Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa. Antioxidants (Basel, Switzerland). 10(7):
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