Gene

gclm

ID
ZDB-GENE-030131-5906
Name
glutamate-cysteine ligase, modifier subunit
Symbol
gclm Nomenclature History
Previous Names
  • GLCLR (1)
  • id:ibd3182
  • wu:fi24c07
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process and positive regulation of glutamate-cysteine ligase activity. Predicted to localize to glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is expressed in several structures, including brain; germ ring; immature eye; liver; and pronephric duct. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
zf3511Allele with one delinsExon 1UnknownCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-gclmZhao et al., 2020
1 - 1 of 1
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Human Disease
Associated With gclm Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Myocardial infarction, susceptibility to} 608446
1 - 1 of 1
Associated With gclm Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR023210 NADP-dependent oxidoreductase domain
Family IPR032963 Glutamate--cysteine ligase regulatory subunit
Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Length Glutamate--cysteine ligase regulatory subunit NADP-dependent oxidoreductase domain NADP-dependent oxidoreductase domain superfamily
UniProtKB:A0A8M3AUZ9 274
UniProtKB:Q803D0 273
1 - 2 of 2
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA gclm-201 (1) Ensembl 1,826 nt
ncRNA gclm-002 (1) Ensembl 525 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-7O6ZFIN Curated Data
ContainsSNPrs3728145
    ZFIN Curated Data
    ContainsSNPrs3728146
      ZFIN Curated Data
      EncodesESTfi24c07
      EncodesESTibd3182Kudoh et al., 2001
      EncodesESTIMAGE:6907712Thisse et al., 2004
      EncodescDNAMGC:55903ZFIN Curated Data
      1 - 7 of 7
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanGCLM1
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (2)
      MouseGclm3
      Amino acid sequence comparison (1)
      Conserved genome location (synteny) (1)
      Citations
      1 - 10 of 40
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