Gene
bard1
- ID
- ZDB-GENE-030131-5883
- Name
- BRCA1 associated RING domain 1
- Symbol
- bard1 Nomenclature History
- Previous Names
-
- si:ch211-207d8.3
- wu:fi23a01 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein K6-linked ubiquitination. Predicted to be part of BRCA1-A complex and BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-bard1 | Thomas et al., 2014 | |
| CRISPR2-bard1 | Shin et al., 2021 | |
| MO1-bard1 | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, susceptibility to} | 114480 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | BRCT domain | BRCT domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QKB4 | InterPro | 653 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207D8 | ZFIN Curated Data | |
| Encodes | EST | fi23a01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021479004 (1) | 3694 nt | ||
| Genomic | GenBank:CR753890 (1) | 201771 nt | ||
| Polypeptide | UniProtKB:A0A8M9QKB4 (1) | 653 aa |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Li, Q., Frank, M., Akiyama, M., Shimizu, H., Ho, S.Y., Thisse, C., Thisse, B., Sprecher, E., and Uitto, J. (2011) Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Disease models & mechanisms. 4(6):777-85
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