Gene
cux1a
- ID
- ZDB-GENE-030131-5868
- Name
- cut-like homeobox 1a
- Symbol
- cux1a Nomenclature History
- Previous Names
-
- fi22b07
- si:ch211-251d10.5
- wu:fi22b07 (1)
- wu:fk35a11
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human CUX1 (cut like homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Oosterhof et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18988 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21764 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21765 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34940 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Global developmental delay with or without impaired intellectual development | 618330 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CUT domain | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Lambda repressor-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QCL4 | InterPro | 1424 | |||||
| UniProtKB:A0A8M2BJZ7 | InterPro | 1480 | |||||
| UniProtKB:A0A8M9Q6L3 | InterPro | 1439 | |||||
| UniProtKB:A0A2R8Q0A5 | InterPro | 1466 | |||||
| UniProtKB:E7F4J9 | InterPro | 1495 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-251D10 | ZFIN Curated Data | |
| Encodes | EST | fi22b07 | ||
| Encodes | EST | fk35a11 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005172718 (1) | 7223 nt | ||
| Genomic | GenBank:AL935293 (2) | 188908 nt | ||
| Polypeptide | UniProtKB:E7F4J9 (1) | 1495 aa |
- Taylor, R., Hamid, F., Fielding, T., Gordon, P.M., Maloney, M., Makeyev, E.V., Houart, C. (2022) Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Nature communications. 13:69946994
- Oosterhof, N., Chang, I.J., Karimiani, E.G., Kuil, L.E., Jensen, D.M., Daza, R., Young, E., Astle, L., van der Linde, H.C., Shivaram, G.M., Demmers, J., Latimer, C.S., Keene, C.D., Loter, E., Maroofian, R., van Ham, T.J., Hevner, R.F., Bennett, J.T. (2019) Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia. American journal of human genetics. 104(5):936-947
- Bergen, D.J.M., Stevenson, N.L., Skinner, R.E.H., Stephens, D.J., Hammond, C.L. (2017) The Golgi matrix protein giantin is required for normal cilia function in zebrafish. Biology Open. 6(8):1180-1189
- Abascal, F., Tress, M., Valencia, A. (2015) The evolutionary fate of alternatively spliced homologous exons after gene duplication. Genome biology and evolution. 7(6):1392-403
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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