Gene

gnsb

ID

ZDB-GENE-030131-5846

Name

glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b

Symbol

gnsb Nomenclature History

Previous Names

gns
wu:fi20h10

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan metabolic process. Predicted to be located in lysosome. Is expressed in pronephric duct and yolk syncytial layer. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55370 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnsb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mucopolysaccharidosis III	Alliance	Mucopolysaccharidosis type IIID	252940
mucopolysaccharidosis type IIID	Alliance	Mucopolysaccharidosis type IIID	252940

Associated With gnsb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000917	Sulfatase, N-terminal
Family	IPR012251	N-acetylglucosamine-6-sulfatase
Homologous_superfamily	IPR017850	Alkaline-phosphatase-like, core domain superfamily