Gene
crp2
- ID
- ZDB-GENE-030131-5826
- Name
- C-reactive protein 2
- Symbol
- crp2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables cholesterol binding activity. Acts upstream of or within defense response to virus and response to bacterium. Predicted to be located in extracellular region. Is expressed in digestive system; fin; gill; immune system; and muscle.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:114100 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| tpu6 | Allele with one delins | Unknown | Unknown | not specified |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Pentaxin, conserved site | Pentraxin domain-containing protein | Pentraxin-related |
|---|---|---|---|---|---|---|
| UniProtKB:F6P334 | InterPro | |||||
| UniProtKB:F1QXE4 | InterPro | 235 | ||||
| UniProtKB:Q7SZ53 | InterPro | 222 | ||||
| UniProtKB:A0A8M2BA52 | InterPro | 223 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-234P6 | ZFIN Curated Data | |
| Encodes | EST | fi20c07 | ||
| Encodes | EST | IMAGE:2601708 | ||
| Encodes | cDNA | MGC:63712 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114100 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192328 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025297 (1) | 1296 nt | ||
| Genomic | GenBank:BX001030 (1) | 155645 nt | ||
| Polypeptide | UniProtKB:F1QXE4 (1) | 235 aa |
No data available
- Saralahti, A.K., Harjula, S.E., Rantapero, T., Uusi-Mäkelä, M.I.E., Kaasinen, M., Junno, M., Piippo, H., Nykter, M., Lohi, O., Rounioja, S., Parikka, M., Rämet, M. (2023) Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genetics. 19:e1010586e1010586
- Shankar, P., Garcia, G.R., LaDu, J.K., Sullivan, C.M., Dunham, C.L., Goodale, B.C., Waters, K.M., Stanisheuski, S., Maier, C.S., Thunga, P., Reif, D.M., Tanguay, R.L. (2022) The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicological sciences : an official journal of the Society of Toxicology. 187(2):325-344
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Bello-Perez, M., Falco, A., Novoa, B., Perez, L., Coll, J. (2019) Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms. PLoS One. 14:e0201509
- M, R., Medina-Gali, ., Belló-Pérez, M., Martínez-López, A., Falcó, A., Ortega-Villaizan, M.M., Encinar, J.A., Novoa, B., Coll, J., Perez, L. (2018) Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. Fish & shellfish immunology. 82:514-521
- Van Gennip, J.L.M., Boswell, C.W., Ciruna, B. (2018) Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Science advances. 4:eaav1781
- Bello-Perez, M., Falco, A., Medina-Gali, R., Pereiro, P., Encinar, J.A., Novoa, B., Perez, L., Coll, J. (2017) Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. Molecular immunology. 91:145-155
- van der Vaart, M., Svoboda, O., Weijts, B.G., Espín-Palazón, R., Sapp, V., Pietri, T., Bagnat, M., Muotri, A.R., Traver, D. (2017) Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.. Disease models & mechanisms. 10(12):1439-1451
- Chen, R., Qi, J., Yuan, H., Wu, Y., Hu, W., Xia, C. (2015) Crystal structures for short-chain pentraxin from zebrafish demonstrate a cyclic trimer with new recognition and effector faces. Journal of structural biology. 189(3):259-68
- Estepa, A., Coll, J. (2015) Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS One. 10:e0135483
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