Gene
alg8
- ID
- ZDB-GENE-030131-5812
- Name
- ALG8 alpha-1,3-glucosyltransferase
- Symbol
- alg8 Nomenclature History
- Previous Names
-
- si:rp71-1p14.2
- wu:fi19e09
- wu:fi19f07 (1)
- zgc:112507
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of or within protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159367 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital disorder of glycosylation Ih | Alliance | Congenital disorder of glycosylation, type Ih | 608104 |
| polycystic liver disease 3 | Alliance | Polycystic liver disease 3 with or without kidney cysts | 617874 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004856 | Glycosyl transferase, ALG6/ALG8 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyl transferase, ALG6/ALG8 |
|---|---|---|---|
| UniProtKB:Q566T2 | InterPro | 524 |
Interactions and Pathways
No data available
Plasmids
No data available