Gene
agfg1a
- ID
- ZDB-GENE-030131-5808
- Name
- ArfGAP with FG repeats 1a
- Symbol
- agfg1a Nomenclature History
- Previous Names
-
- agfg1
- hrb (1)
- wu:fb14f05
- wu:fi19d11
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Predicted to be active in cytoplasmic vesicle. Is expressed in intermediate cell mass of mesoderm and ventral mesoderm. Orthologous to human AGFG1 (ArfGAP with FG repeats 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63481 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa35962 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Arf-GAP domain and FG repeat-containing protein | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf GTPase activating protein |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QBV1 | InterPro | 596 | ||||
| UniProtKB:Q6TEN4 | InterPro | 556 | ||||
| UniProtKB:A0A8M3ASW7 | InterPro | 572 | ||||
| UniProtKB:A0A8M3AQ06 | InterPro | 532 | ||||
| UniProtKB:A0A8M9QH37 | InterPro | 580 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
agfg1a-202
(1)
|
Ensembl | 785 nt | ||
| mRNA |
agfg1a-201
(1)
|
Ensembl | 2,581 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158N6 | ZFIN Curated Data | |
| Contains | SNP | rs3728744 | ZFIN Curated Data | |
| Contains | SNP | rs3728745 | ZFIN Curated Data | |
| Contains | SNP | rs3728746 | ZFIN Curated Data | |
| Contains | SNP | rs3728747 | ZFIN Curated Data | |
| Encodes | EST | fb14f05 | ZFIN Curated Data | |
| Encodes | EST | fi19d11 | ||
| Encodes | cDNA | MGC:63481 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199835 (1) | 2545 nt | ||
| Genomic | GenBank:CR354553 (1) | 143156 nt | ||
| Polypeptide | UniProtKB:A0A8M9QBV1 (1) | 596 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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