Gene

arid1ab

ID

ZDB-GENE-030131-5725

Name

AT-rich interactive domain 1Ab

Symbol

arid1ab Nomenclature History

Previous Names

fb82h08
fi15b05
im:7160733
si:dkey-180c19.1
wu:fb82h08
wu:fi15b05

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex and nBAF complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 2; breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7160733 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arid1ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Coffin-Siris syndrome 2	Alliance	Coffin-Siris syndrome 2	614607

Associated With arid1ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001606	ARID DNA-binding domain
Domain	IPR033388	SWI/SNF-like complex subunit BAF250, C-terminal
Family	IPR021906	SWI/SNF-like complex subunit BAF250/Osa
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR036431	ARID DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	ARID DNA-binding domain	ARID DNA-binding domain superfamily	Armadillo-like helical	SWI/SNF-like complex subunit BAF250, C-terminal	SWI/SNF-like complex subunit BAF250/Osa
UniProtKB:A0A8M9PSC1 InterPro	2261

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arid1ab-202 (1) Ensembl	Ensembl	6,303 nt	Select Tool ZFIN BLAST
mRNA	arid1ab-203 (1) Ensembl	Ensembl	10,429 nt	Select Tool ZFIN BLAST
ncRNA	arid1ab-002 (1) Ensembl	Ensembl	475 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations