Gene

mthfd2l

ID

ZDB-GENE-030131-5707

Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like

Symbol

mthfd2l Nomenclature History

Previous Names

wu:fi14c12
zgc:63479

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable methenyltetrahydrofolate cyclohydrolase activity and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lee et al., 2012

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mthfd2l Human Ortholog

No data available

Associated With mthfd2l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020867	Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Domain	IPR020630	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain	IPR020631	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family	IPR000672	Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily
Homologous_superfamily	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily