Gene
slc30a7
- ID
- ZDB-GENE-030131-5650
- Name
- solute carrier family 30 member 7
- Symbol
- slc30a7 Nomenclature History
- Previous Names
-
- wu:fi11a08
- zgc:55366
- ZnT7
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in intracellular zinc ion homeostasis and zinc ion import into Golgi lumen. Predicted to act upstream of or within zinc ion transport. Predicted to be located in Golgi cis cisterna membrane; mitochondrion; and sarcoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including blastoderm; notochord; prechordal plate; pronephric duct; and yolk. Orthologous to human SLC30A7 (solute carrier family 30 member 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ziegler-Huang syndrome | 620501 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cation efflux protein | Cation efflux transmembrane domain superfamily | Zinc transporter Msc2-like |
|---|---|---|---|---|
|
UniProtKB:A5PMX1
|
387 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc30a7-201
(1)
|
Ensembl | 1,942 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190N7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-270E10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-6P9 | ZFIN Curated Data | |
| Encodes | EST | fi11a08 | ||
| Encodes | cDNA | MGC:55366 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174110 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191957 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100086 (1) | 1942 nt | ||
| Genomic | GenBank:BX908733 (1) | 134155 nt | ||
| Polypeptide | UniProtKB:A5PMX1 (1) | 387 aa |
- Secli, V., Di Biagio, C., Martini, A., Michetti, E., Pacello, F., Ammendola, S., Battistoni, A. (2023) Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes. International Journal of Molecular Sciences. 24(2):
- Kong, N., Zhao, Q., Liu, C., Li, J., Liu, Z., Gao, L., Wang, L., Song, L. (2020) The involvement of zinc transporters in the zinc accumulation in the Pacific oyster Crassostrea gigas. Gene. 750:144759
- Zhao, L., Tan, J., Li, D., Jiang, L., Li, T., Yang, Y., Wang, G., Shang, Z., Wang, J., Zhou, J. (2019) SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish. Biochemical and Biophysical Research Communications. 511(4):896-902
- Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
- Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Ho, E., Dukovcic, S., Hobson, B., Wong, C.P., Miller, G., Hardin, K., Traber, M.G., and Tanguay, R.L. (2012) Zinc transporter expression in zebrafish (Danio rerio) during development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(1):26-32
- Yan, G., Zhang, Y., Yu, J., Yu, Y., Zhang, F., Zhang, Z., Wu, A., Yan, X., Zhou, Y., and Wang, F. (2012) Slc39a7/zip7 Plays a Critical Role in Development and Zinc Homeostasis in Zebrafish. PLoS One. 7(8):e42939
- Kambe, T., Suzuki, T., Nagao, M., and Yamaguchi-Iwai, Y. (2006) Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters. Genomics, proteomics & bioinformatics. 4(1):1-9
- Feeney, G.P., Zheng, D., Kille, P., and Hogstrand. C. (2005) The phylogeny of teleost ZIP and ZnT zinc transporters and their tissue specific expression and response to zinc in zebrafish. BBA Gene Structure and Expression. 1732(1-3):88-95
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