Gene

kcnd3

ID
ZDB-GENE-030131-5626
Name
potassium voltage-gated channel, Shal-related subfamily, member 3
Symbol
kcnd3 Nomenclature History
Previous Names
  • wu:fi06g01
  • zgc:55306
  • zShal3 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits voltage-gated potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to localize to several cellular components, including dendritic spine; postsynaptic density; and voltage-gated potassium channel complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnd3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brugada syndrome 9 Alliance Brugada syndrome 9 616399
spinocerebellar ataxia type 19/22 Alliance Spinocerebellar ataxia 19 607346
Associated With kcnd3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Domain IPR003131 Potassium channel tetramerisation-type BTB domain
Domain IPR005821 Ion transport domain
Domain IPR021645 Shal-type voltage-gated potassium channels, N-terminal
Domain IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
Family IPR003968 Potassium channel, voltage dependent, Kv
Family IPR003975 Potassium channel, voltage dependent, Kv4
Family IPR004056 Potassium channel, voltage dependent, Kv4.3
Family IPR028325 Voltage-gated potassium channel
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length BTB/POZ domain Ion transport domain Potassium channel tetramerisation-type BTB domain Potassium channel, voltage dependent, Kv Potassium channel, voltage dependent, Kv4 Potassium channel, voltage dependent, Kv4.3 Potassium channel, voltage dependent, Kv4, C-terminal Shal-type voltage-gated potassium channels, N-terminal SKP1/BTB/POZ domain superfamily Voltage-dependent channel domain superfamily Voltage-gated potassium channel
UniProtKB:Q7ZW36 638
UniProtKB:A0A286Y962 650
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations