Gene

kcnd3

ID

ZDB-GENE-030131-5626

Name

potassium voltage-gated channel, Shal-related subfamily, member 3

Symbol

kcnd3 Nomenclature History

Previous Names

wu:fi06g01
zgc:55306
zShal3 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion export across plasma membrane. Predicted to act upstream of or within potassium ion transmembrane transport and protein homooligomerization. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendritic spine; neuronal cell body; and postsynaptic membrane. Is expressed in heart and nervous system. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55306 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnd3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Brugada syndrome 9	Alliance	Brugada syndrome 9	616399
spinocerebellar ataxia type 19/22	Alliance	Spinocerebellar ataxia 19	607346

Associated With kcnd3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR003131	Potassium channel tetramerisation-type BTB domain
Domain	IPR005821	Ion transport domain
Domain	IPR021645	Shal-type voltage-gated potassium channels, N-terminal
Domain	IPR024587	Potassium channel, voltage dependent, Kv4, C-terminal
Family	IPR003968	Potassium channel, voltage dependent, Kv
Family	IPR003975	Potassium channel, voltage dependent, Kv4
Family	IPR004056	Potassium channel, voltage dependent, Kv4.3
Family	IPR028325	Voltage-gated potassium channel
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily